Q: Name two binding interactions necessary for T cell proliferation and differentiation.
A: TCR:MHC-antigen and CD28:B7

Q: What is the primary cytokine responsible for T cell proliferation and differentiation?
A: IL-2

Q: True or False TCRs are MHC restricted and antigen specific?
A: True

Q: TCRs are made up of how many different proteins?  What are their names and the associations?
A: 4, alpha:beta and gamma:delta

Q: Which TCR chains contain D regions?
A: beta and delta

Q: How many core heterodimers does each TCR contain?
A: one, either alpha:beta or gamma:delta

Q: Distortion upon seeing MHC:antigen leads to what?
A: CD3 activation signaling

Q: What are the two co-receptor molecules for T cells and which is more common?
A: CD4 and CD8; CD4 is more common (65%)

Q: Which MHC do CD4 and CD8 T cells recognize and what are they more commonly known as, respectively?
A: CD4: MHC II, helper T   CD8: MHC I, CTL or cytotoxic T cell

Q: What are the effector functions of helper T and cytotoxic T cells, respectively?
A: secrete cytokines(helper); kill target cells(CTL)

Q: Name the eight polypeptides that compose the complete TCR complex
A: one core heterodimer, either alpha:beta or gamma:delta; two CD3 dimers (1 CD3gamma, 1CD3delta, 2CD3epsilon), 2 zeta chains