Q: Which serious recurrent bacterial infection is most commonly seen with an antibody deficiency? 
A: Sinopulmonary infections 

Q: The increase of monoclonal antibody such as IgG during an antibody deficiency syndrome may have what effect on other hormone levels? 
A: It depresses them. 

Q: Which type of immunity is not acquired from your mother? 
A: T-cell immunity 

Q: Stem cell abnormality, IL-2 receptor defect, ADA deficiency, and signal transduction defects are the features of which immune deficiency? 
A: Severe Combined Immune Deficiency 

Q: What is the typical duration of transient hypogammaglobulinemia? 
A: Two years 

Q: How is hypogammaglobulinemia typically treated? 
A: Immunize and check response. No treatment needed. 

Q: What major feature do Bruton’s Agammaglobulinemia and Hyper-IGM Syndrome share? 
A: Both are X-linked. 

Q: Which disease involves a B-cell tyrosine kinase gene abnormality? 
A: Bruton’s Agammaglobulinemia. 

Q: Bruton's Agammaglobulinemia is characterized by what (deficiency)? 
A: Absence or very low quantities of Ig on the surface of mature B-cells. 

Q: Bruton's Agammaglobulinemia: what part of the antibody is present in the pre B-cell cytoplasm? 
A: Mu heavy chains 

Q: Bruton's Agammaglobulinemia: why do infections begin between 4-6 months of age? 
A: Mother's immunoglobulin disappears. 

Q: Hyper-IGM Syndrome: what levels of IgM are common (2)? 
A: Normal to increased IgM 

Q: What is the cause of the deficiency of IgG,IgA, and IgE in Hyper-IGM Syndrome? 
A: Defect in class switching by block at IgM B-cell. 

Q: Hyper-IGM Syndrome: Lack of which B-cell ligand is responsible for the deficiency in class switiching? 
A: The CD40 ligand. 

Q: Is an immunoglobulin A deficiency common or rare? 
A: Very common 

Q: A clinical presentation of allergy, eczema, food allergies, with no immune exclusion of harmful antigens: which deficiency? 
A: IgA deficiency. 

Q: Should blood and blood products given to IgA deficient patients contain/not contain IgA? 
A: Not contain IgA- these can cause severe allergic reactions. 

Q: When is the onset of Common Variable Hypogammaglobulinemia? 
A: Several years after birth to 90 years. 

Q: Common Variable Hypogammaglobulinemia: what cells are involved? 
A: B and T cells 

Q: What type of infections are most common in Common Variable Hypogammaglobulinemia? 
A: Sinopulmonary infections. 

Q: What is the most common clinical symptom in Common Variable Hypogammaglobulinemia? 
A: Diarrhea 

Q: What growth factor deficiency is related to Common Variable Hypogammaglobulinemia? 
A: IL-2 deficiency 

Q: Herpes zoster, herpes simplex, cytomegalovirus, and enteroviral meningoencephalitis are viral infections associated with which immunodeficiency? 
A: Common Variable Hypogammaglobulinemia? 

Q: Common Variable Hypogammaglobulinemia: what is its etiology? 
A: Failure to terminally differentiate to plasma cells. 

Q: What are four indicated therapies for antibody deficiencies? 
A: Prevent life-threatening infections, decrease pulmonary damage, eradicate localized infection, replace gammaglobulin (in most instances). 

Q: What is one major hazard of gammaglobulin therapy? 
A: Anaphylaxis due to Ig’s 

Q: Recurrent bacterial infections, low IgG, and no antibody formation when immunized may indicated therapy (and route) for patients with hypogammaglobulinemia? 
A: IVIG